Making labor safer for

               women and their babies

Association of Morphologic Entropy in Fetal ECG with
Inflammatory Cytokines and Markers of Neuronal Injury

Objective:

To evaluate the use of fetal ECG entrophy to predict fetal inflammation.

 

Methods:

Fetal EKG data were recorded during
labor using a GE Corometric 120
® fetal
monitor from six women who had a
scalp electrode placed for a clinical
indication at term. We measured the
morphologic entropy of the fetal ECG
signal using an unsupervised
algorithm.

The algorithm first partitioned heart
beats into classes of activity based on
their morphology, and then computed
the entropy of the symbolic sequence
obtained by replacing each beat in the
original signal with a label
corresponding to its morphologic class.

 

 

 

Methods (cont'd):

Interleukin-6 (IL-6), IL-8, and neuron-specific enolase (NSE) levels were measurd in the umbilical cord serum.

 

 

 

Results:

Morphologic entrophy showed
a statistically significant linear accociation (p<0.05) with IL-6, IL-8, and NSE levels.

There wa no association observed between heart-rate variability and any of the measured serum levels.

 

 

 

Conclusions:

Morphologic entrophy of the fetal ECG signal may provide a noninvasive means to detect inflammation prior to the development of chorioamnionitis.

 

 

 

Zeeshan Syed, PhD,1,2 Adam Wolfberg, MD, MPH,3,4 John Guttag, PhD.1

1Massachusetts Institute of Technology, 2University of Michigan, 3Tufts Medical Center, 4Children’s Hospital, Boston

Acknowledgement: Center for the Integration of Medicine and Innovative Technology (CIMIT). Industrial Technology Research Institute Taiwan. Texas Instruments, Obstetrix, Research Grant.

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